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KMID : 1141920230390020156
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Annals of Coloproctology
2023 Volume.39 No. 2 p.156 ~ p.163
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The albumin to globulin ratio is associated with clinical outcome in Japanese patients with ulcerative colitis
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Sen Yagi
Shinya Furukawa
Kana Shiraishi
Teruki Miyake
Kazuhiro Tange
Yu Hashimoto
Shogo Kitahata
Tomoe Kawamura
Tomoyuki Ninomiya
Kenichirou Mori
Seiyuu Suzuki
Naozumi Shibata
Hidehiro Murakami
Katsuhisa Ohashi
Aki Hasebe
Hideomi Tomida
Yasunori Yamamoto
Eiji Takeshita
Yoshio Ikeda
Yoichi Hiasa
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Abstract
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Purpose: The albumin-to-globulin ratio (AGR) is a recognized chronic inflammation marker. No evidence regarding the relationship between AGR level and ulcerative colitis (UC) exists. The aim of this study was to evaluate the association between AGR and clinical outcomes among Japanese subjects with UC.
Methods: The study subjects consisted of 273 Japanese individuals with UC. AGR was divided into 4 categories (low, moderate, high, and very high). The definition of complete mucosal healing (MH) was based on the Mayo endoscopic subscore of 0. Clinical remission (CR) was defined as no rectal bleeding and no abnormally high stool frequency (<3 times per day).
Results: The percentage of MH was 26.4%. High AGR and very high AGR were significantly positively correlated with CR (adjusted odds ratio [OR], 5.85; 95% confidence interval [CI], 2.52?14.18 and adjusted OR, 4.97; 95% CI, 2.14?12.04) and complete MH (adjusted OR, 4.03; 95% CI, 1.56?11.51 and adjusted OR, 5.22; 95% CI, 1.97?14.89), respectively after adjustment for confounding factors (P for trend=0.001). Only in the low C-reactive protein (CRP) group (≤0.1 mg/dL), very high AGR was significantly positively correlated with complete MH but not CR (adjusted OR, 4.38; 95% CI, 1.06?21.77; P for trend=0.017). In the high CRP group, no correlation between AGR and complete MH was found.
Conclusion: Among Japanese patients with UC, AGR may be independently positively correlated with complete MH. In particular, among UC patients with low CRP, AGR might be a useful complementary marker for complete MH.
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KEYWORD
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Biomarker, Endoscopy, Ulcerative colitis
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